RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin SynthesisMaruyama et al. provide evidence from mouse experiments that fecal single-stranded RNA (ssRNA) is sensed in the gut by the cation channel Piezo1. They show that ssRNA-stimulated Piezo1 is involved in peristalsis and gut serotonin synthesis and reduced bone mass. The ssRNA-Peizo1 axis reported could be a prophylactic target for treatment of bone and gut disorders, including the side effects of certain serotonergic drugs.Maruyama et al. provide evidence from mouse experiments that fecal single-stranded RNA (ssRNA) is sensed in the gut by the cation channel Piezo1. They show that ssRNA-stimulated Piezo1 is involved in peristalsis and gut serotonin synthesis and reduced bone mass. The ssRNA-Peizo1 axis reported could be a prophylactic target for treatment of bone and gut disorders, including the side effects of certain serotonergic drugs.Erika Sugisawa, Yasunori Takayama, Naoki Takemura, Takeshi Kondo, Shigetsugu Hatakeyama, Yutaro Kumagai, Masataka Sunagawa, Makoto Tominaga, Kenta Maruyamahttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2820%2930754-6%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 8, 2020

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