Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNAThe innate immune receptor cGAS interacts with PI(4,5)P2 in order to localize to the plasma membrane, which is critical to prevent aberrant interferon responses to self-DNA under conditions of genotoxic stress, as well as to properly sense viral infections.The innate immune receptor cGAS interacts with PI(4,5)P2 in order to localize to the plasma membrane, which is critical to prevent aberrant interferon responses to self-DNA under conditions of genotoxic stress, as well as to properly sense viral infections.Katherine C. Barnett, Julia M. Coronas-Serna, Wen Zhou, Michael J. Ernandes, Anh Cao, Philip J. Kranzusch, Jonathan C. Kaganhttps://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=https%3A%2F%2Fwww.cell.com%2Fcell%2Ffulltext%2FS0092-8674%2819%2930112-6%3Frss%3Dyes&rc=0http://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignMarch 1, 2019

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