Engineered nucleocytosolic vehicles for loading of programmable editorsEngineered nucleocytosolic vehicles for loading of programmable editors (ENVLPE) with enhanced CRISPR ribonucleoprotein (RNP) loading and stabilization enable the efficient delivery of gene-editing effectors, such as nuclease, base, and prime editors. ENVLPE+ outperforms existing VLP systems for ex vivo and in vivo gene editing, including the restoration of gene function in retinal disease models.Engineered nucleocytosolic vehicles for loading of programmable editors (ENVLPE) with enhanced CRISPR ribonucleoprotein (RNP) loading and stabilization enable the efficient delivery of gene-editing effectors, such as nuclease, base, and prime editors. ENVLPE+ outperforms existing VLP systems for ex vivo and in vivo gene editing, including the restoration of gene function in retinal disease models.Julian Geilenkeuser, Niklas Armbrust, Emily Steinmaßl, Samuel W. Du, Sebastian Schmidt, Eva Maria Hildegard Binder, Yuchun Li, Niklas Wilhelm Warsing, Stephanie Victoria Wendel, Florian von der Linde, Elisa Marie Schiele, Xiya Niu, Luisa Stroppel, Oleksandr Berezin, Tobias Heinrich Santl, Tanja Orschmann, Keith Nelson, Christoph Gruber, Grazyna Palczewska, Carolline Rodrigues Menezes, Eleonora Risaliti, Zachary J. Engfer, Naile Koleci, Andrea Schmidts, Arie Geerlof, Krzysztof Palczewski, Gil Gregor Westmeyer, Dong-Jiunn Jeffery Truonghttps://www.cell.com/cell/fulltext/S0092-8674(25)00288-0?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignApril 10, 2025

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