TMPRSS2 and glycan receptors synergistically facilitate coronavirus entryCoronavirus entry is initiated by the recognition of proteinaceous and/or glycan receptors. Here, cryo-EM analysis of the HCoV-HKU1 spike in the inactive, glycan-activated, and functionally anchored states demonstrates that TMPRSS2 and sialoglycan synergistically facilitate the entry of HCoV-HKU1. Further insights into the interaction mode between TMPRSS2 and the spike are provided, as well as the potential host range of HCoV-HKU1. These data enhance our understanding of viral-host interaction during entry.Coronavirus entry is initiated by the recognition of proteinaceous and/or glycan receptors. Here, cryo-EM analysis of the HCoV-HKU1 spike in the inactive, glycan-activated, and functionally anchored states demonstrates that TMPRSS2 and sialoglycan synergistically facilitate the entry of HCoV-HKU1. Further insights into the interaction mode between TMPRSS2 and the spike are provided, as well as the potential host range of HCoV-HKU1. These data enhance our understanding of viral-host interaction during entry.Haofeng Wang, Xiaoce Liu, Xiang Zhang, Zhuoqian Zhao, Yuchi Lu, Dingzhe Pu, Zeyang Zhang, Jie Chen, Yajie Wang, Mengfei Li, Xuxue Dong, Yinkai Duan, Yujia He, Qiyu Mao, Hangtian Guo, Haoran Sun, Yihan Zhou, Qi Yang, Yan Gao, Xiuna Yang, Hongzhi Cao, Luke Guddat, Lei Sun, Zihe Rao, Haitao Yanghttps://www.cell.com/cell/fulltext/S0092-8674(24)00656-1?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 4, 2024

Powered by WPeMatico