Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirusTMPRSS2 is a cell-surface protease synthesized as a zymogen that undergoes autocleavage to reach its active conformation, which involves conformational changes on key exposed activation loops. The HKU1 seasonal coronavirus uses TMPRSS2 as entry receptor, with the spike protein recognizing the activation loops and inserting a motif into the protease’s catalytic groove.TMPRSS2 is a cell-surface protease synthesized as a zymogen that undergoes autocleavage to reach its active conformation, which involves conformational changes on key exposed activation loops. The HKU1 seasonal coronavirus uses TMPRSS2 as entry receptor, with the spike protein recognizing the activation loops and inserting a motif into the protease’s catalytic groove.Ignacio Fernández, Nell Saunders, Stéphane Duquerroy, William H. Bolland, Atousa Arbabian, Eduard Baquero, Catherine Blanc, Pierre Lafaye, Ahmed Haouz, Julian Buchrieser, Olivier Schwartz, Félix A. Reyhttps://www.cell.com/cell/fulltext/S0092-8674(24)00647-0?rss=yeshttp://www.cell.com/cell/inpress.rssCellCell RSS feed.Wireless News CampaignJuly 4, 2024

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